{"id":7543,"date":"2020-10-19T08:02:00","date_gmt":"2020-10-19T06:02:00","guid":{"rendered":"https:\/\/voxvigor.se\/?p=7543"},"modified":"2020-10-19T08:02:00","modified_gmt":"2020-10-19T06:02:00","slug":"klinisk-studie-om-ny-behandling-av-ptsd","status":"publish","type":"post","link":"https:\/\/voxvigor.se\/bricks-staging\/klinisk-studie-om-ny-behandling-av-ptsd\/","title":{"rendered":"Klinisk studie om ny behandling av PTSD"},"content":{"rendered":"\n

Professor Markus Heilig och bitr\u00e4dande universitetslektor Leah Mayo, Link\u00f6pings universitet<\/p>\n\n\n\n

<\/p>\n\n\n\n

Forskare vid Link\u00f6pings universitet startar en klinisk studie. De vill unders\u00f6ka om ett l\u00e4kemedel i kombination med internetbaserad kognitiv beteendeterapi, KBT, kan lindra post-traumatiskt stressyndrom, PTSD. Det \u00e4r f\u00f6rsta g\u00e5ngen detta l\u00e4kemedel, och den biologiska mekanismen bakom, pr\u00f6vas mot PTSD. Det \u00e4r ocks\u00e5 nytt att kombinera KBT med l\u00e4kemedel som sannolikt f\u00f6rst\u00e4rker effekter av den psykologiska behandlingen.<\/strong><\/h5>\n\n\n\n


Post-traumatiskt stressyndrom \u00e4r en \u00e5ngestsjukdom som kan uppst\u00e5 efter att man upplevt ett trauma<\/a>, som en livshotande h\u00e4ndelse. Den drabbade undviker ofta situationer och platser som v\u00e4cker minnen av traumat, och personens liv blir mycket begr\u00e4nsat av sjukdomen.<\/p>\n\n\n\n

Inte f\u00e5tt diagnos trots mardr\u00f6mmar och \u00e5ngest<\/h6>\n\n\n\n

\u2013 M\u00e5nga med PTSD har inte f\u00e5tt en diagnos. En del som varit med om sv\u00e5ra traumatiska h\u00e4ndelser upplever sig \u00f6versk\u00f6ljda av en intensiv \u00e5ngest som triggas av minnen. De har mardr\u00f6mmar och andra symtom, men s\u00e4tter inte etiketten PTSD p\u00e5 det, s\u00e4ger Markus Heilig. Han \u00e4r professor i psykiatri vid Institutionen f\u00f6r biomedicinska och kliniska vetenskaper (BKV) och f\u00f6rest\u00e5ndare f\u00f6r Centrum f\u00f6r social och affektiv neurovetenskap (CSAN) vid Link\u00f6pings universitet (LiU).<\/p>\n\n\n\n

F\u00f6r dem som blir diagnosticerade med PTSD \u00e4r den b\u00e4sta behandlingen en s\u00e4rskild kognitiv beteendeterapi, KBT. Den g\u00e5r ut p\u00e5 att man p\u00e5 ett kontrollerat s\u00e4tt rekonstruerar minnena av traumat. Med st\u00f6d av en behandlare exponerar sig patienten p\u00e5 ett systematiskt s\u00e4tt f\u00f6r minnena, vilket kan f\u00e5 r\u00e4dslominnena att klinga av.<\/p>\n\n\n\n

\u2013 Tyv\u00e4rr \u00e4r det sv\u00e5rt att f\u00e5 en fullst\u00e4ndig utsl\u00e4ckning av r\u00e4dslominnena. \u00c4ven om behandlingen var framg\u00e5ngsrik, \u00e5terkommer traumaminnena ofta med tiden, s\u00e4ger Markus Heilig.<\/p>\n\n\n\n

\"\"
Professor Markus Heilig<\/figcaption><\/figure>\n\n\n\n


I den kliniska studie som nu startar kommer forskarna att testa om effekten av KBT kan bli f\u00f6rst\u00e4rkt med ett l\u00e4kemedel som \u00e4r under utveckling, JNJ-42165279. LiU-forskarna har tidigare visat i en experimentell studie p\u00e5 friska personer att l\u00e4kemedlet har en lovande effekt p\u00e5 hj\u00e4rnans f\u00f6rm\u00e5ga till ny inl\u00e4rning. P\u00e5 det s\u00e4ttet signalerar de skr\u00e4mmande minnena inte l\u00e4ngre fara. L\u00e4kemedlet h\u00f6jer niv\u00e5n av en av kroppens egna cannabis-liknande substanser i hj\u00e4rnan. Dessa spelar en viktig roll i hur vi reagerar p\u00e5 stress och obehag.<\/p>\n\n\n\n

\u2013 V\u00e5r f\u00f6rhoppning \u00e4r att vi genom att kombinera KBT med l\u00e4kemedel ska kunna f\u00f6rst\u00e4rka utsl\u00e4ckningen av r\u00e4dslominnen. Vi hoppas ocks\u00e5 p\u00e5 att l\u00e4kemedlet ska skydda mot starka negativa k\u00e4nslor och att det ska hj\u00e4lpa patienterna att stanna kvar i behandlingen, s\u00e4ger Markus Heilig.<\/p>\n\n\n\n

Deltagarnas hj\u00e4rnaktivitet m\u00e4ts med magnetkamera<\/h6>\n\n\n\n

Unikt i studien \u00e4r att forskarna kommer att unders\u00f6ka deltagarnas hj\u00e4rnaktivitet med funktionell magnetresonanstomografi, fMRI, eller magnetkamera som det ocks\u00e5 kallas. Leah Mayo, bitr\u00e4dande universitetslektor, leder den delen av studien. Hon \u00e4r s\u00e4rskilt intresserad av om l\u00e4kemedlet f\u00f6rst\u00e4rker kommunikationen mellan tv\u00e5 specifika omr\u00e5den i hj\u00e4rnan. \u00c4r det i s\u00e5 fall m\u00f6jligt att koppla ihop s\u00e5dana m\u00e4tbara f\u00f6r\u00e4ndringar med kliniska resultat av behandlingen?<\/p>\n\n\n\n

\"\"
Professor Gerhard Andersson<\/figcaption><\/figure>\n\n\n\n


I studien kommer 90 personer med PTSD f\u00e5 internetbaserad KBT som utvecklats av professor Gerhard Anderssons forskargrupp vid LiU. Den h\u00f6r till de fr\u00e4msta i v\u00e4rlden inom omr\u00e5det.<\/p>\n\n\n\n

Internetbaserad KBT ger flexibilitet f\u00f6r deltagarna<\/h6>\n\n\n\n

\u2013 Deltagaren kan n\u00e5 den internetbaserade KBT-behandlingen n\u00e4r det passar honom eller henne b\u00e4st. Dessutom \u00e4r det l\u00e4tt att ta pauser, repetera och p\u00e5 s\u00e5 vis anpassa arbetet med behandlingen. Deltagaren f\u00e5r st\u00f6d fr\u00e5n behandlaren via behandlingsplattformen i n\u00e4ra anslutning till uppgifterna. I vanlig KBT kan det beh\u00f6va g\u00e5 flera dagar till n\u00e4sta tr\u00e4ff med behandlaren. S\u00e5 internet kan vara ett bra alternativ f\u00f6r den som vill jobba sj\u00e4lvst\u00e4ndigt och beh\u00f6ver lite extra tid f\u00f6r att sm\u00e4lta inneh\u00e5llet i en KBT-behandling, s\u00e4ger professor Gerhard Andersson vid Institutionen f\u00f6r beteende och l\u00e4rande, IBL, och Institutionen f\u00f6r biomedicinska och kliniska vetenskaper, BKV.<\/p>\n\n\n\n

H\u00e4lften av deltagarna kommer dessutom att bli lottade till att f\u00e5 l\u00e4kemedlet. Den andra h\u00e4lften blir kontrollgruppen som f\u00e5r sockerpiller (placebo). L\u00e4kemedelsbehandlingen sker under tolv veckor och under de sista \u00e5tta av dessa veckor genomg\u00e5r deltagarna internet-KBT.<\/p>\n\n\n\n

Markus Heilig leder den kliniska studien som genomf\u00f6rs i samarbete med l\u00e4kemedelsf\u00f6retaget Janssen. Mer information hittar ni p\u00e5\u00a0s<\/a>tudiens webbplats.<\/a><\/p>\n\n\n\n


Foton: <\/strong>Pressbilder fr\u00e5n Link\u00f6pings universitet<\/p>\n","protected":false},"excerpt":{"rendered":"

Professor Markus Heilig och bitr\u00e4dande universitetslektor Leah Mayo, Link\u00f6pings universitet Forskare vid Link\u00f6pings universitet startar en klinisk studie. De vill unders\u00f6ka om ett l\u00e4kemedel i kombination med internetbaserad kognitiv beteendeterapi, […]<\/p>\n","protected":false},"author":6,"featured_media":7545,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4],"tags":[],"acf":[],"yoast_head":"\nKlinisk studie om ny behandling av PTSD - Bricks staging<\/title>\n<meta name=\"description\" content=\"Forskare vid Link\u00f6pings universitet startar en klinisk studie. 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