{"id":10777,"date":"2023-01-12T15:08:42","date_gmt":"2023-01-12T14:08:42","guid":{"rendered":"https:\/\/voxvigor.se\/?p=10777"},"modified":"2023-01-12T15:08:42","modified_gmt":"2023-01-12T14:08:42","slug":"modell-forklarar-hur-autism-uppstar","status":"publish","type":"post","link":"https:\/\/voxvigor.se\/bricks-staging\/modell-forklarar-hur-autism-uppstar\/","title":{"rendered":"Modell f\u00f6rklarar hur autism uppst\u00e5r"},"content":{"rendered":"\n

Nu kan det bli l\u00e4ttare att f\u00f6rst\u00e5 hur autism uppst\u00e5r, tack vare en f\u00f6rklaringsmodell som presenteras i en avhandling fr\u00e5n G\u00f6teborgs universitet. Modellen ger nya insikter om hur olika riskfaktorer ger upphov till autism och varf\u00f6r variationen inom autism \u00e4r s\u00e5 stor.<\/strong>
<\/h2>\n\n\n\n


Autism \u00e4r en utvecklingsrelaterad funktionsavvikelse som p\u00e5verkar hur en person uppfattar omv\u00e4rlden och hur hen samspelar och kommunicerar med andra. Det finns stora skillnader mellan individer med autism, b\u00e5de personliga egenskaper och hur autismen visar sig. Autism brukar d\u00e4rf\u00f6r beskrivas som ett spektrum, med m\u00e5nga olika nyanser.<\/p>\n\n\n\n

Den nya f\u00f6rklaringsmodellen \u00e4r teoretisk, men samtidigt konkret eftersom dess olika delar g\u00e5r att m\u00e4ta med exempelvis fr\u00e5geformul\u00e4r, genetisk kartl\u00e4ggning och psykologiska tester. Modellen beskriver olika bidragande faktorer och hur dessa samverkar f\u00f6r att ge upphov till en autismdiagnos, och \u00e4ven andra utvecklingsneurologiska funktionsavvikelser.<\/p>\n\n\n\n

Tre bidragande faktorer<\/strong><\/h3>\n\n\n\n

Modellen kopplar samman tre bidragande faktorer som tillsammans leder till ett s\u00e5dant beteendem\u00f6nster att en person uppfyller kriterierna f\u00f6r att diagnostiseras med autism:<\/p>\n\n\n\n

1. Autistisk personlighet; vanliga och \u00e4rftliga genetiska varianter som ger upphov till autistiska personlighetsdrag.<\/p>\n\n\n\n

2. Kognitiv kompensation; intelligens och exekutiva funktioner, exempelvis f\u00f6rm\u00e5ga att l\u00e4ra sig, f\u00f6rst\u00e5 omgivningen och anpassa sig till sociala interaktioner.<\/p>\n\n\n\n

3. Exponering f\u00f6r riskfaktorer; exempelvis skadliga genetiska varianter, infektioner och andra slumpartade h\u00e4ndelser under graviditet och tidig barndom som har en negativ p\u00e5verkan p\u00e5 kognitiv f\u00f6rm\u00e5ga.<\/p>\n\n\n\n

\u2013 Den autistiska personligheten \u00e4r associerad med b\u00e5de kognitiva styrkor och sv\u00e5righeter. Men den leder inte till uppfyllande av diagnoskriterier av sig sj\u00e4lv. Exponering f\u00f6r riskfaktorer som h\u00e4mmar den kognitiva f\u00f6rm\u00e5gan kan dock p\u00e5verka f\u00f6rm\u00e5gan att hantera sv\u00e5righeterna. Det bidrar till att en individ f\u00e5r diagnosen autism, s\u00e4ger Darko Sarovic. Han \u00e4r l\u00e4kare och disputerad forskare p\u00e5 Sahlgrenska akademin vid G\u00f6teborgs universitet och har skrivit avhandlingen.<\/p>\n\n\n\n

Modellen tydligg\u00f6r hur samspelet mellan alla tre faktorer tillsammans leder till diagnos, och f\u00f6resl\u00e5r att det framf\u00f6rallt \u00e4r exponering f\u00f6r olika riskfaktorer som leder till de stora skillnaderna mellan individer inom spektrat. De olika delarna i modellen har st\u00f6d i resultat fr\u00e5n tidigare forskning. Att \u00e4rftlighet har stor betydelse f\u00f6r om en person uppfyller diagnoskriterier f\u00f6r autism \u00e4r k\u00e4nt sedan tidigare.<\/p>\n\n\n\n

F\u00f6rm\u00e5ga till anpassning<\/strong><\/h3>\n\n\n\n

En person med h\u00f6g exekutiv f\u00f6rm\u00e5ga kan kompensera f\u00f6r funktionsneds\u00e4ttningen s\u00e5 att symtomen mildras. Det minskar risken att uppfylla diagnoskriterier f\u00f6r autism. Detta kan f\u00f6rklara varf\u00f6r forskare p\u00e5 gruppniv\u00e5 ser en l\u00e4gre niv\u00e5 av intelligens bland personer som blivit diagnostiserade med s\u00e5v\u00e4l autism som andra utvecklingsneurologiska tillst\u00e5nd. Det ger ocks\u00e5 f\u00f6rst\u00e5else f\u00f6r varf\u00f6r intellektuell funktionsneds\u00e4ttning \u00e4r vanligare bland dessa grupper. Modellen pekar allts\u00e5 p\u00e5 att l\u00e5g kognitiv f\u00f6rm\u00e5ga inte \u00e4r en del av den autistiska personligheten, utan en riskfaktor som leder till att diagnoskriterier blir uppfyllst<\/p>\n\n\n\n

\u2013 Den autistiska personligheten \u00e4r associerad med diverse styrkor. Exempelvis \u00e4r f\u00f6r\u00e4ldrar till barn med autism \u00f6verrepresenterade bland ingenj\u00f6rer och matematiker. Sannolikt har f\u00f6r\u00e4ldrarna d\u00e5 sj\u00e4lva kunnat kompensera f\u00f6r sin egen autistiska personlighet och d\u00e4rmed inte uppfyllt kriterierna f\u00f6r autismdiagnos. Genomslaget har sedan blivit mer p\u00e5tagligt f\u00f6r deras barn, exempelvis p\u00e5 grund av exponering f\u00f6r riskfaktorer och en relativt l\u00e4gre kognitiv f\u00f6rm\u00e5ga, s\u00e4ger Darko Sarovic.<\/p>\n\n\n\n

Skillnad mellan flickor och pojkar<\/strong><\/p>\n\n\n\n

Diagnosen autism \u00e4r vanligare bland pojkar \u00e4n flickor, och flickor f\u00e5r ofta sin diagnos senare i livet. En del flickor hinner bli vuxna innan de f\u00e5tt diagnosen, efter m\u00e5nga \u00e5r av diffusa personliga sv\u00e5righeter.<\/p>\n\n\n\n

\u2013 Flickors symtom \u00e4r ofta mindre i\u00f6gonfallande f\u00f6r omgivningen. Det \u00e4r v\u00e4lk\u00e4nt att flickor \u00f6verlag har h\u00f6gre kompetens inom sociala funktioner. Det inneb\u00e4r sannolikt att de \u00e4r b\u00e4ttre p\u00e5 att kompensera f\u00f6r sina sv\u00e5righeter. Flickor tenderar ocks\u00e5 att ha f\u00e4rre autistiska drag och vara mindre k\u00e4nsliga f\u00f6r effekterna av riskfaktorer. Modellen kan allts\u00e5 bidra till svar om k\u00f6nsskillnaden, s\u00e4ger Darko Sarovic.<\/p>\n\n\n\n

Forskning och diagnostik<\/strong><\/h3>\n\n\n\n

Modellen f\u00f6resl\u00e5r ocks\u00e5 s\u00e4tt att uppskatta och m\u00e4ta de tre faktorerna (autistisk personlighet, kognitiv kompensation och riskfaktorer). Det inneb\u00e4r att modellen kan vara anv\u00e4ndbar vid planering av forskningsstudier och tolkning av dess resultat.<\/p>\n\n\n\n

\u00c4ven diagnostik \u00e4r ett t\u00e4nkbart anv\u00e4ndningsomr\u00e5de. I en pilotstudie med 24 personer diagnostiserade med autism och 22 kontrollpersoner utan autism kunde man med hj\u00e4lp av att m\u00e4ta modellens tre faktorer korrekt placera \u00f6ver 93 procent i r\u00e4tt kategori. Den \u00e4r \u00e4ven anv\u00e4ndbart f\u00f6r att f\u00f6rklara uppkomsten av andra utvecklingsneurologiska tillst\u00e5nd, exempelvis schizofreni.<\/p>\n\n\n\n

Darko Sarovic har nu en forskartj\u00e4nst vid Harvard Medical School i Boston, USA, och \u00e4r samtidigt fortsatt knuten till Gillbergcentrum vid G\u00f6teborgs universitet.
<\/p>\n\n\n\n

Titel<\/strong>: A Multimodal Approach toward the Biological Categorization of Autism \u2013 Development of Theoretical Models, Classification Methods, and Biomarkers, https:\/\/hdl.handle.net\/2077\/73553<\/a><\/p>\n\n\n\n

<\/p>\n\n\n\n


Foto<\/strong>: Mikhail Nilov fr\u00e5n Pexels (genrebild)<\/p>\n","protected":false},"excerpt":{"rendered":"

Nu kan det bli l\u00e4ttare att f\u00f6rst\u00e5 hur autism uppst\u00e5r, tack vare en f\u00f6rklaringsmodell som presenteras i en avhandling fr\u00e5n G\u00f6teborgs universitet. 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